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    Cryogenic electron microscopy system with 300 kV transmission cryo-electron microscope and cryogenic focused ion beam scanning electron microscope

    University of Helsinki

    Cryogenic electron microscopy system with 300 kV transmission cryo-electron microscope and cryogenic focused ion beam scanning electron microscope

    1. Competition notice published

      Oct 13, 2025 6:32 AMOctober 13, 2025 6:32 AM

    2. Supplier selection

      Nov 24, 2025 12:00 AMNovember 24, 2025 12:00 AM

    3. Contract signed

      Dec 8, 2025 12:00 AMDecember 8, 2025 12:00 AM

    4. Result notice published

      Dec 18, 2025 8:33 AMDecember 18, 2025 8:33 AM

    Brief

    Finland: Tenders/University of Helsinki/Cryogenic electron microscopy system with 300 kV transmission cryo-electron microscope and cryogenic focused ion beam scanning electron microscope

    Awarded

    The competition has ended and a winner has been selected.

    Deadline
    Dec 17, 2025Expired
    Award
    Highest number of tomography-based structures 10% and 13 more
    Procedure
    OpenSingle stage
    Agreement
    Buying goods
    Estimated value
    €5.7Mover 5 months

    Brief

    University of Helsinki has entered into an agreement with FEI Europe B.V. - Branch Denmark for the delivery of a cryogenic electron microscopy system, including a 300 kV transmission cryo-electron microscope and a cryogenic focused ion beam scanning electron microscope. The system will be delivered to Helsinki-Uusimaa, Finland, with a project duration of 5 months, at a total value of 6,664,836 EUR. The system must be capable of loading 10 or more samples at once, hold samples at 90 K or lower, and the cryo-FIBSEM cryo-stage must cool to at least -170 °C in under 30 minutes and maintain cryogenic conditions for 20 hours or more without liquid nitrogen dewar refill. The cryo-FIBSEM must also have a 360-degree continuous rotation of the cryo-stage and documented use in tomography applications in at least three peer-reviewed scientific publications with structures reporting resolution better than 8 Å. The current Falcon 4i detector must be installable on the new microscope.

    Laboratorie- og analyseutstyr

    Result

    TED
    • FEI Europe BV. Branch Denmark
      Winner
    • Number of bids
      0
    • Contract value
      €6,664,836

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    Award Criteria

    • Description

      The total price must be indicated as a fixed net price excluding VAT (in EUR, VAT 0 %, maximum 5 720 000 euros). The total price must include delivery costs, insurance costs, installation of the equipment so that it is fully operational, the necessary test drives, user and maintenance instructions, training and regular maintenance during the warranty period (total 20 points).

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Highest number of tomography-based structures obtained using the cryo-TEM instrument or its predecessor at better than 5 Å (0.143 FCS) resolution deposited in EMDB.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Sustainability: The current Falcon 4i detector can be installed on the new microscope by the supplier.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Service contract at fixed price (full service, including unlimited work and parts, and remote support) for an additional four years for both instruments, lowest price.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Cryo-TEM can be loaded with 10 or more samples at one go.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Cryo-TEM can hold samples at temperature of 90 K or lower inside the microscope.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Maximum Cryo-FIBSEM cryo-stage movement range on the x and y axes (x, y range) (largest stage area available).

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Documented use of provider cryo-FIBSEM instrument in tomography applications in at least three peer-reviewed scientific publications with structures reporting resolution better than 8 Å (0.143 FCS).

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      360 degree rotation of the cryo-FIBSEM cryo-stage should be fully continuous in both directions.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Number of years of extended warranty beyond 1 year provided.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Cryo-FIBSEM cryo-stage must cool down to at least -170 °C, in less than 30 minutes.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Cryo-FIBSEM can hold cryogenic conditions for 20 hours or more without liquid nitrogen dewar refill.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      Viewing of the samples and chamber in FIBSEM instrument should be possible via live cryo-compatible IR CCD camera.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      The delivered microscopes come without third-party components.

      Source

      No source found in the documents. Check the weight against the tender documents.

    • Description

      The warranty and extended warranty include automated software to check on daily basis the status of the microscope, a regional customer manager and portal/online access for operational parameters to monitor the system status and history for at least the first 3 years.

      Source

      No source found in the documents. Check the weight against the tender documents.

    Previous winners

    • Who are you up against?

      The suppliers who have won similar contracts at University of Helsinki

    From the notice

    • The Institute of Biotechnology Structural Biology Platform (INSTRUCT-HiLFE) will be upgrading its cryogenic electron microscopy (cryo-EM) services. The current 200 kV transmission electron microscope will be replaced with equipment offering higher resolution for both single-particle and tomography analysis. To enable this, we will establish an integrated workflow for producing samples for tomography and single-particle analysis. Specifically, we will acquire a 300 kV cryogenic transmission electron microscope (cryo-TEM) suitable for high-resolution structural biology, together with a software and hardware compatible cryogenic focused ion beam scanning electron microscope (cryo-FIBSEM) for lamella sample preparation required in high-resolution tomography. The instruments will be installed at the Institute of Biotechnology, University of Helsinki (UH). Delivery and installation will take place in 2027.

    • Contact

      Hankinnathankinnat@helsinki.fi
    • Type
      Result
    • Location
      Helsinki-Uusimaa
    • Main code
      Microscopes
      38510000

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