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    Microscale thermophoresis device

    Oulun yliopisto

    Microscale thermophoresis device

    1. Competition notice published

      Aug 26, 8:02 AMAugust 26, 2026 8:02 AM

    2. Questions deadline

      Sep 18, 9:00 AMSeptember 18, 2026 9:00 AM

    3. Tender submission deadline

      Oct 9, 1:00 PMOctober 9, 2026 1:00 PM

    4. Opening date

      Oct 12, 6:00 AMOctober 12, 2026 6:00 AM

    5. Tender validity period

      Apr 9, 1:00 PMApril 9, 2027 1:00 PM

    Brief

    Tender search/Oulun yliopisto/Microscale thermophoresis device
    Brief

    Laboratorie- og analyseutstyr

    Oulun yliopisto needs a spectral shift and microscale thermophoresis device for Biocenter Oulu, with a maximum total value of 189,000 EUR (excluding VAT). The device will be used to characterize and quantify nanoparticle interactions, including proteins, in solution without immobilization, and must enable assessment of sample quality and aggregation, differentiating binding events from aggregation. It needs to detect interactions based on changes in the emission spectrum of an excited fluorophore under isothermal conditions and create a microscopic non-isothermal temperature field to determine binding events based on temperature-related intensity changes and fluorescence intensity changes following thermophoresis. The device must have a measurable dynamic range of dissociation constant of at least nM-mM and binding affinity in at least nM-mM range, with low sample consumption (around 10 microlitres) and low nanomole of the labeled target. The contract duration is 36 months. The award criterion is the total price, weighted at 100%.

    About the bid

      University of Oulu, Biocenter Oulu, seeks a spectral shift and microscale thermophoresis device to characterise qualitatively and determine quantitatively nanoparticle, including protein, interactions in the range of weak to tight binders in solution without immobilization (hereinafter referred to as the "device"). The device must enable the assessment of sample quality and aggregation and differentiating binding events from aggregation. The device will be used for analysis of interactions of fluorescence labelled proteins with small molecules and vesicles. The detection must be independent of the mass ratio of the binding partners. The device must enable fast screening of interactions as well as sensitive affinity measurement. The measurable dynamic range of dissociation constant must be at least in nM -mM range and binding affinity in at least nM -mM range. Low sample consumption (in order of 10 microlitre) and low nanomole of the labeled target is needed for the measurement. The device must enable detection of the interaction based on changes of emission spectrum of exited fluorophore under isothermal conditions and must be able to create a microscopic non-isothermal temperature field (temperature gradient) and determine nanoparticle including protein binding events based on the temperature related intensity change and fluorescence intensity change following thermophoresis under the thermal gradient. Intensity changes and/or spectrum shifts of the fluorescence probe versus ligand concentrations are measured and plotted to calculate the dissociation constant. The device must come with detailed documentation of all features. The device will be part of the Proteomics and protein analysis core facility infrastructure of Biocenter Oulu. The core facility has an open access policy, and the instrumentation and software must be easy to use and maintain. The device must include a user interface to control the operation. The device must be well suited to an academic multi-user environment. The contracting entity has a maximum sum of 189000 € (excluding value-added tax) available for the procurement and cannot accept tenders exceeding this amount. The procurement is partially funded by the European Regional Development Funds (ERDF), BioParts project (A81573).

      Contact name
      Procurement Services
      Contact phone
      +358 505663159
      Contact email
      hankinnat@oulu.fi
      Address
      Pentti Kaiteran katu 1 / PL 8000, 90570 OULU

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    See the full notice

    Contracting authority
    Oulun yliopisto
    Title
    Microscale thermophoresis device
    Type
    CompetitionPrequalification
    Main code
    38000000Laboratory, optical and precision equipments (excl. glasses)
    Supplemental codes

    No supplemental codes from buyer…

    Supplemental codes added by Cobrief

    38400000Instruments for checking physical characteristics
    38430000Detection and analysis apparatus
    38500000Checking and testing apparatus
    Location
    Pohjois-Pohjanmaa
    Duration
    36 months

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